Drug interactions
Everolimus + Somatrogon
Severity: Minor
Everolimus and Somatrogon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone products may increase the activity of some CYP450 enzymes, which could modestly lower blood concentrations of CYP3A4 substrates such as everolimus. Reduced everolimus exposure could weaken its immunosuppressive or antitumour effect.
What this interaction means in plain words
Everolimus and Somatrogon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Everolimus belongs to Oncology; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone may induce CYP3A4-mediated metabolism, potentially increasing everolimus clearance; the evidence is limited.
What to do
Monitor everolimus trough concentrations and clinical response when somatrogon is started or stopped. Adjust the everolimus dose according to levels.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Everolimus with Somatrogon?
MediHelp rates the interaction as minor. Everolimus and Somatrogon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone products may increase the activity of some CYP450 enzymes, which could modestly lower blood concentrations of CYP3A4 substrates such as everolimus. Reduced everolimus exposure could weaken its immunosuppressive or antitumour effect.
How serious is the interaction between Everolimus and Somatrogon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations and clinical response when somatrogon is started or stopped. Adjust the everolimus dose according to levels.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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