Drug interactions
Everolimus + Sotorasib
Severity: Moderate
Everolimus and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a moderate CYP3A4 inducer and can lower everolimus concentrations, but it may also inhibit P-gp, which could raise them. The net effect is unpredictable, and either loss of efficacy or toxicity is possible.
What this interaction means in plain words
Everolimus and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Sotorasib belongs to Oncology.
Why it happens
Sotorasib induces CYP3A4 and inhibits P-glycoprotein, producing opposing effects on everolimus exposure.
What to do
Monitor everolimus trough concentrations after starting or stopping sotorasib and adjust the dose to target. Watch for both toxicity and reduced efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Everolimus with Sotorasib?
MediHelp rates the interaction as moderate. Everolimus and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a moderate CYP3A4 inducer and can lower everolimus concentrations, but it may also inhibit P-gp, which could raise them. The net effect is unpredictable, and either loss of efficacy or toxicity is possible.
How serious is the interaction between Everolimus and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations after starting or stopping sotorasib and adjust the dose to target. Watch for both toxicity and reduced efficacy.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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