Drug interactions
Exemestane + Tucatinib
Severity: Moderate
Exemestane and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and may raise exemestane concentrations. Exemestane has a wide therapeutic margin, so clinically significant toxicity is unlikely but possible.
What this interaction means in plain words
Exemestane and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Exemestane belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by tucatinib reduces exemestane clearance.
What to do
No empiric exemestane dose change is needed. Monitor for adverse effects such as fatigue, arthralgia and hot flashes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Exemestane
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Exemestane with Tucatinib?
MediHelp rates the interaction as moderate. Exemestane and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a strong CYP3A inhibitor and may raise exemestane concentrations. Exemestane has a wide therapeutic margin, so clinically significant toxicity is unlikely but possible.
How serious is the interaction between Exemestane and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric exemestane dose change is needed. Monitor for adverse effects such as fatigue, arthralgia and hot flashes.
What other medicines interact with Exemestane?
MediHelp also lists interactions of Exemestane with, for example, Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol. The full list is on the Exemestane page.
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