Drug interactions
Exenatide + Medroxyprogesterone
Severity: Minor
Exenatide and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins such as medroxyprogesterone can modestly impair glucose tolerance and may weaken the glucose-lowering effect of exenatide. Glycemic control may drift upward in people with diabetes, particularly with higher-dose or depot use.
What this interaction means in plain words
Exenatide and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Exenatide belongs to Endocrine; Medroxyprogesterone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: progestins may reduce insulin sensitivity and glucose tolerance, opposing incretin-mediated glucose lowering.
What to do
Monitor blood glucose and HbA1c when medroxyprogesterone is started or stopped. Adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Exenatide
- Chlorpropamide + Exenatide Major
- Asenapine + Exenatide Moderate
- Betamethasone + Exenatide Moderate
- Chlorothiazide + Exenatide Moderate
- Clozapine + Exenatide Moderate
- Cortisone + Exenatide Moderate
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Exenatide with Medroxyprogesterone?
MediHelp rates the interaction as minor. Exenatide and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins such as medroxyprogesterone can modestly impair glucose tolerance and may weaken the glucose-lowering effect of exenatide. Glycemic control may drift upward in people with diabetes, particularly with higher-dose or depot use.
How serious is the interaction between Exenatide and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when medroxyprogesterone is started or stopped. Adjust the antidiabetic regimen if control worsens.
What other medicines interact with Exenatide?
MediHelp also lists interactions of Exenatide with, for example, Chlorpropamide, Asenapine, Betamethasone. The full list is on the Exenatide page.
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