Drug interactions
Ezogabine + Fluconazole
Severity: Moderate
Ezogabine and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine can prolong the QT interval, and fluconazole has similar potential. Together they may add to the risk of QT prolongation and arrhythmia, especially at higher ezogabine doses.
What this interaction means in plain words
Ezogabine and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG and correct electrolyte abnormalities when the combination is used. Avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Fluconazole?
MediHelp rates the interaction as moderate. Ezogabine and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine can prolong the QT interval, and fluconazole has similar potential. Together they may add to the risk of QT prolongation and arrhythmia, especially at higher ezogabine doses.
How serious is the interaction between Ezogabine and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct electrolyte abnormalities when the combination is used. Avoid adding other QT-prolonging drugs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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