Drug interactions
Ezogabine + Goserelin
Severity: Moderate
Ezogabine and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Goserelin, an androgen deprivation agent, can prolong the QT interval, and ezogabine has also been linked to small QT changes. Using them together may add to the risk of QT prolongation and torsades de pointes, especially in patients with other risk factors.
What this interaction means in plain words
Ezogabine and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Goserelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation; androgen deprivation lengthens repolarization while ezogabine has a modest effect on the QT interval.
What to do
Obtain a baseline ECG and repeat it after starting or titrating either drug, and correct potassium and magnesium abnormalities. Reconsider the combination if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezogabine
Other interactions of Goserelin
Frequently asked questions
Can I take Ezogabine with Goserelin?
MediHelp rates the interaction as moderate. Ezogabine and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Goserelin, an androgen deprivation agent, can prolong the QT interval, and ezogabine has also been linked to small QT changes. Using them together may add to the risk of QT prolongation and torsades de pointes, especially in patients with other risk factors.
How serious is the interaction between Ezogabine and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it after starting or titrating either drug, and correct potassium and magnesium abnormalities. Reconsider the combination if the QTc becomes markedly prolonged.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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