Drug interactions
Ezogabine + Hydroxychloroquine
Severity: Major
Ezogabine and Hydroxychloroquine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine was associated with QT prolongation, and hydroxychloroquine adds to this effect, increasing the risk of arrhythmia. Ezogabine has been withdrawn from the market in many regions.
What this interaction means in plain words
Ezogabine and Hydroxychloroquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ezogabine belongs to Central Nervous System; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Additive delayed ventricular repolarization.
What to do
Avoid the combination and use an alternative antiepileptic if ezogabine remains in use. If unavoidable, monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Hydroxychloroquine?
MediHelp rates the interaction as major. Ezogabine and Hydroxychloroquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ezogabine was associated with QT prolongation, and hydroxychloroquine adds to this effect, increasing the risk of arrhythmia. Ezogabine has been withdrawn from the market in many regions.
How serious is the interaction between Ezogabine and Hydroxychloroquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiepileptic if ezogabine remains in use. If unavoidable, monitor ECG and electrolytes.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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