Drug interactions
Ezogabine + Lenvatinib
Severity: Moderate
Ezogabine and Lenvatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so using them together may increase the risk of ventricular arrhythmias such as torsades de pointes. The risk is greater with electrolyte disturbances, heart disease or higher ezogabine doses.
What this interaction means in plain words
Ezogabine and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Lenvatinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QT interval) through pharmacodynamic effects of both drugs.
What to do
Obtain a baseline ECG and monitor it periodically during co-treatment. Correct potassium, magnesium and calcium abnormalities and reduce doses or stop one drug if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ezogabine and Lenvatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ezogabine
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Ezogabine with Lenvatinib?
MediHelp rates the interaction as moderate. Ezogabine and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so using them together may increase the risk of ventricular arrhythmias such as torsades de pointes. The risk is greater with electrolyte disturbances, heart disease or higher ezogabine doses.
How serious is the interaction between Ezogabine and Lenvatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically during co-treatment. Correct potassium, magnesium and calcium abnormalities and reduce doses or stop one drug if the QTc becomes markedly prolonged.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
