Drug interactions
Ezogabine + Lopinavir
Severity: Moderate
Ezogabine and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine can lengthen the QT interval, and lopinavir/ritonavir has also been associated with QT and PR interval prolongation. Combined use may add to the risk of arrhythmia, especially in patients with cardiac disease or electrolyte imbalance.
What this interaction means in plain words
Ezogabine and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
Why it happens
Additive effects on cardiac repolarization from both drugs.
What to do
Check a baseline ECG and monitor the QT interval during co-administration. Correct electrolyte abnormalities and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezogabine
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Ezogabine with Lopinavir?
MediHelp rates the interaction as moderate. Ezogabine and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine can lengthen the QT interval, and lopinavir/ritonavir has also been associated with QT and PR interval prolongation. Combined use may add to the risk of arrhythmia, especially in patients with cardiac disease or electrolyte imbalance.
How serious is the interaction between Ezogabine and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor the QT interval during co-administration. Correct electrolyte abnormalities and avoid adding other QT-prolonging drugs.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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