Drug interactions
Ezogabine + Ondansetron
Severity: Major
Ezogabine and Ondansetron: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine can prolong the QT interval, and adding ondansetron may increase the risk of ventricular arrhythmia. Patients with cardiac disease or electrolyte disturbances are especially vulnerable.
What this interaction means in plain words
Ezogabine and Ondansetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ezogabine belongs to Central Nervous System; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Avoid where possible and use another antiemetic. If combined, monitor the ECG and keep potassium and magnesium in the normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Ondansetron?
MediHelp rates the interaction as major. Ezogabine and Ondansetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ezogabine can prolong the QT interval, and adding ondansetron may increase the risk of ventricular arrhythmia. Patients with cardiac disease or electrolyte disturbances are especially vulnerable.
How serious is the interaction between Ezogabine and Ondansetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible and use another antiemetic. If combined, monitor the ECG and keep potassium and magnesium in the normal range.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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