Drug interactions
Ezogabine + Ozanimod
Severity: Moderate
Ezogabine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and affect cardiac conduction, and ezogabine can prolong the QT interval. Using them together may increase the risk of arrhythmia, particularly bradycardia-related torsades de pointes.
What this interaction means in plain words
Ezogabine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Additive effects on cardiac conduction, with ozanimod-related bradycardia and ezogabine-related QT prolongation.
What to do
Obtain an ECG before starting ozanimod and monitor heart rate and QTc. Seek specialist advice if QTc is prolonged or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezogabine
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ezogabine with Ozanimod?
MediHelp rates the interaction as moderate. Ezogabine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and affect cardiac conduction, and ezogabine can prolong the QT interval. Using them together may increase the risk of arrhythmia, particularly bradycardia-related torsades de pointes.
How serious is the interaction between Ezogabine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod and monitor heart rate and QTc. Seek specialist advice if QTc is prolonged or bradycardia develops.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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