Drug interactions
Ezogabine + Risperidone
Severity: Moderate
Ezogabine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT interval prolongation, and risperidone can add to this effect, so the arrhythmia risk may rise. Ezogabine also causes somnolence and dizziness that may be additive with risperidone.
What this interaction means in plain words
Ezogabine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and additive CNS depression.
What to do
Obtain a baseline ECG and repeat after dose titration, especially in patients with cardiac risk factors. Monitor for sedation and correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ezogabine and Risperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Risperidone?
MediHelp rates the interaction as moderate. Ezogabine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT interval prolongation, and risperidone can add to this effect, so the arrhythmia risk may rise. Ezogabine also causes somnolence and dizziness that may be additive with risperidone.
How serious is the interaction between Ezogabine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after dose titration, especially in patients with cardiac risk factors. Monitor for sedation and correct electrolyte disturbances.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
