Drug interactions
Ezogabine + Trimipramine
Severity: Moderate
Ezogabine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation, and trimipramine can add to this effect. Ezogabine may also cause sedation and urinary retention, which could be additive with tricyclic effects.
What this interaction means in plain words
Ezogabine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CNS depressant and urinary retention effects.
What to do
Obtain a baseline ECG and repeat it after dose changes, keeping electrolytes normal. Monitor for sedation and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Trimipramine?
MediHelp rates the interaction as moderate. Ezogabine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT prolongation, and trimipramine can add to this effect. Ezogabine may also cause sedation and urinary retention, which could be additive with tricyclic effects.
How serious is the interaction between Ezogabine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it after dose changes, keeping electrolytes normal. Monitor for sedation and urinary retention.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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