Drug interactions
Famotidine + Mefloquine
Severity: Moderate
Famotidine and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine has been associated with QT prolongation, mainly in renal impairment, and mefloquine can also affect cardiac conduction. Combined use may add to arrhythmia risk, although the clinical risk is low in most patients.
What this interaction means in plain words
Famotidine and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Famotidine belongs to Gastrointestinal Tract; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible additive QT-interval prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium in higher-risk patients, especially those with renal impairment. Reduce famotidine dose in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Famotidine with Mefloquine?
MediHelp rates the interaction as moderate. Famotidine and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Famotidine has been associated with QT prolongation, mainly in renal impairment, and mefloquine can also affect cardiac conduction. Combined use may add to arrhythmia risk, although the clinical risk is low in most patients.
How serious is the interaction between Famotidine and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium in higher-risk patients, especially those with renal impairment. Reduce famotidine dose in renal impairment.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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