Drug interactions
Fedratinib + Fluticasone-salmeterol
Severity: Moderate
Fedratinib and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may raise exposure to fluticasone and salmeterol, though the effect on inhaled drugs is likely modest. Increased systemic exposure could produce corticosteroid effects or beta-agonist cardiovascular effects.
What this interaction means in plain words
Fedratinib and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated metabolism of fluticasone and salmeterol.
What to do
Monitor for tachycardia, palpitations, tremor and signs of systemic corticosteroid excess. Reassess the dose of the inhaler if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Fedratinib and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may raise exposure to fluticasone and salmeterol, though the effect on inhaled drugs is likely modest. Increased systemic exposure could produce corticosteroid effects or beta-agonist cardiovascular effects.
How serious is the interaction between Fedratinib and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tachycardia, palpitations, tremor and signs of systemic corticosteroid excess. Reassess the dose of the inhaler if adverse effects appear.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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