Drug interactions
Fedratinib + Ifosfamide
Severity: Moderate
Fedratinib and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and CYP2C19, which participate in ifosfamide metabolism, so it may change the balance of active and toxic metabolites. The clinical effect is uncertain and based on prediction.
What this interaction means in plain words
Fedratinib and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Ifosfamide belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and CYP2C19 by fedratinib alters ifosfamide metabolism.
What to do
Monitor for ifosfamide efficacy and toxicity, including neurotoxicity and myelosuppression. Adjust the ifosfamide dose according to tolerance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Ifosfamide?
MediHelp rates the interaction as moderate. Fedratinib and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and CYP2C19, which participate in ifosfamide metabolism, so it may change the balance of active and toxic metabolites. The clinical effect is uncertain and based on prediction.
How serious is the interaction between Fedratinib and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ifosfamide efficacy and toxicity, including neurotoxicity and myelosuppression. Adjust the ifosfamide dose according to tolerance.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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