Drug interactions
Fedratinib + Imipramine
Severity: Moderate
Fedratinib and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP2D6 and CYP2C19, both involved in imipramine metabolism, and can raise imipramine and desipramine concentrations. This increases the risk of anticholinergic effects, sedation, hypotension and arrhythmias.
What this interaction means in plain words
Fedratinib and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Imipramine belongs to Central Nervous System.
Why it happens
Fedratinib inhibits CYP2D6 and CYP2C19, reducing imipramine clearance.
What to do
Monitor for tricyclic adverse effects and ECG changes, and reduce the imipramine dose as needed. Consider tricyclic plasma level monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Imipramine?
MediHelp rates the interaction as moderate. Fedratinib and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP2D6 and CYP2C19, both involved in imipramine metabolism, and can raise imipramine and desipramine concentrations. This increases the risk of anticholinergic effects, sedation, hypotension and arrhythmias.
How serious is the interaction between Fedratinib and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and ECG changes, and reduce the imipramine dose as needed. Consider tricyclic plasma level monitoring.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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