Drug interactions
Fedratinib + Irinotecan
Severity: Moderate
Fedratinib and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and may raise exposure to irinotecan and its active metabolite SN-38 through reduced oxidative clearance of the parent drug. Because CYP3A4 oxidation produces inactive metabolites of irinotecan, inhibition may shift handling and increase toxicity such as neutropenia and diarrhea. The clinical significance is uncertain, as irinotecan activation by carboxylesterases is not affected.
What this interaction means in plain words
Fedratinib and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Irinotecan belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, reducing oxidative metabolism of irinotecan.
What to do
Monitor blood counts and diarrhea closely when combining the agents, and consider irinotecan dose reduction if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Irinotecan?
MediHelp rates the interaction as moderate. Fedratinib and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and may raise exposure to irinotecan and its active metabolite SN-38 through reduced oxidative clearance of the parent drug. Because CYP3A4 oxidation produces inactive metabolites of irinotecan, inhibition may shift handling and increase toxicity such as neutropenia and diarrhea. The clinical significance is uncertain, as irinotecan activation by carboxylesterases is not affected.
How serious is the interaction between Fedratinib and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and diarrhea closely when combining the agents, and consider irinotecan dose reduction if toxicity develops.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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