Drug interactions
Fedratinib + Metformin-repaglinide
Severity: Moderate
Fedratinib and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and can raise exposure to repaglinide, increasing the risk of hypoglycemia.
What this interaction means in plain words
Fedratinib and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Metformin-repaglinide belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated repaglinide metabolism by fedratinib.
What to do
Monitor blood glucose closely and reduce the repaglinide dose if hypoglycemia occurs during fedratinib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Fedratinib and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and can raise exposure to repaglinide, increasing the risk of hypoglycemia.
How serious is the interaction between Fedratinib and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the repaglinide dose if hypoglycemia occurs during fedratinib therapy.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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