Drug interactions
Fedratinib + Nilotinib
Severity: Major
Fedratinib and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and can raise nilotinib exposure. Increased nilotinib levels heighten the risk of QT prolongation and other dose-related toxicities. Fedratinib itself carries serious toxicities, which compounds the concern.
What this interaction means in plain words
Fedratinib and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fedratinib belongs to Oncology; Nilotinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, reducing nilotinib clearance.
What to do
Avoid the combination if possible; otherwise obtain a baseline ECG and monitor the QTc and electrolytes closely. Consider reducing the nilotinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Nilotinib?
MediHelp rates the interaction as major. Fedratinib and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fedratinib is a moderate CYP3A4 inhibitor and can raise nilotinib exposure. Increased nilotinib levels heighten the risk of QT prolongation and other dose-related toxicities. Fedratinib itself carries serious toxicities, which compounds the concern.
How serious is the interaction between Fedratinib and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise obtain a baseline ECG and monitor the QTc and electrolytes closely. Consider reducing the nilotinib dose.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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