Drug interactions
Fedratinib + Nortriptyline
Severity: Moderate
Fedratinib and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP2D6, which is the main pathway for nortriptyline hydroxylation, so nortriptyline levels may rise. This can increase anticholinergic effects, sedation and cardiac conduction effects.
What this interaction means in plain words
Fedratinib and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Nortriptyline belongs to Central Nervous System.
Why it happens
Fedratinib inhibits CYP2D6, reducing nortriptyline clearance.
What to do
Monitor for tricyclic adverse effects and consider reducing the nortriptyline dose. Use plasma level monitoring and an ECG if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Nortriptyline?
MediHelp rates the interaction as moderate. Fedratinib and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP2D6, which is the main pathway for nortriptyline hydroxylation, so nortriptyline levels may rise. This can increase anticholinergic effects, sedation and cardiac conduction effects.
How serious is the interaction between Fedratinib and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider reducing the nortriptyline dose. Use plasma level monitoring and an ECG if toxicity is suspected.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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