Drug interactions
Fedratinib + Praziquantel
Severity: Moderate
Fedratinib and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase praziquantel exposure. This could heighten dose-related adverse effects of praziquantel.
What this interaction means in plain words
Fedratinib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Praziquantel belongs to Anti Parasitic.
Why it happens
Fedratinib inhibits CYP3A4, decreasing praziquantel metabolism.
What to do
Monitor for increased praziquantel adverse effects such as dizziness and sedation. Counsel the patient about driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Praziquantel?
MediHelp rates the interaction as moderate. Fedratinib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may increase praziquantel exposure. This could heighten dose-related adverse effects of praziquantel.
How serious is the interaction between Fedratinib and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased praziquantel adverse effects such as dizziness and sedation. Counsel the patient about driving and machinery.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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