Drug interactions
Fedratinib + Quinine
Severity: Moderate
Fedratinib and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and can increase quinine exposure. Higher quinine levels raise the risk of cinchonism, hypoglycemia and QT prolongation.
What this interaction means in plain words
Fedratinib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Fedratinib inhibits CYP3A4-mediated metabolism of quinine.
What to do
Monitor for quinine toxicity and consider an ECG. Reduce the quinine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Quinine?
MediHelp rates the interaction as moderate. Fedratinib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and can increase quinine exposure. Higher quinine levels raise the risk of cinchonism, hypoglycemia and QT prolongation.
How serious is the interaction between Fedratinib and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity and consider an ECG. Reduce the quinine dose if adverse effects occur.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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