Drug interactions
Fedratinib + Salmeterol
Severity: Moderate
Fedratinib and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4, which is the main route of salmeterol clearance, so salmeterol exposure may rise. This can increase tremor, tachycardia and QT effects.
What this interaction means in plain words
Fedratinib and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Salmeterol belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated salmeterol metabolism by fedratinib.
What to do
Monitor for tachycardia, palpitations, tremor and hypokalemia, and consider ECG if symptomatic. Consider an alternative bronchodilator if effects are excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Salmeterol?
MediHelp rates the interaction as moderate. Fedratinib and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4, which is the main route of salmeterol clearance, so salmeterol exposure may rise. This can increase tremor, tachycardia and QT effects.
How serious is the interaction between Fedratinib and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tachycardia, palpitations, tremor and hypokalemia, and consider ECG if symptomatic. Consider an alternative bronchodilator if effects are excessive.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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