Drug interactions
Fedratinib + Selegiline
Severity: Minor
Fedratinib and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolized by CYP3A4, CYP2C19 and CYP2C9, and selegiline is a weak inhibitor of some of these enzymes at most. The clinical effect on fedratinib exposure has not been established and is likely small.
What this interaction means in plain words
Fedratinib and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Selegiline belongs to Central Nervous System.
Why it happens
Possible weak CYP inhibition by selegiline; mechanism not clearly established.
What to do
No dose adjustment is established. Monitor for fedratinib toxicity such as gastrointestinal effects and cytopenias.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Selegiline?
MediHelp rates the interaction as minor. Fedratinib and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is metabolized by CYP3A4, CYP2C19 and CYP2C9, and selegiline is a weak inhibitor of some of these enzymes at most. The clinical effect on fedratinib exposure has not been established and is likely small.
How serious is the interaction between Fedratinib and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is established. Monitor for fedratinib toxicity such as gastrointestinal effects and cytopenias.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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