Drug interactions
Fedratinib + Sorafenib
Severity: Moderate
Fedratinib and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and could raise sorafenib exposure. Sorafenib is only partly cleared via CYP3A4, so the effect is probably modest, but adverse reactions may increase.
What this interaction means in plain words
Fedratinib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, reducing sorafenib oxidative metabolism.
What to do
Monitor for sorafenib adverse effects, including skin toxicity, hypertension and diarrhea. Reduce the dose or interrupt treatment if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Sorafenib?
MediHelp rates the interaction as moderate. Fedratinib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and could raise sorafenib exposure. Sorafenib is only partly cleared via CYP3A4, so the effect is probably modest, but adverse reactions may increase.
How serious is the interaction between Fedratinib and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib adverse effects, including skin toxicity, hypertension and diarrhea. Reduce the dose or interrupt treatment if toxicity develops.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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