Drug interactions
Fedratinib + Tamoxifen
Severity: Moderate
Fedratinib and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and CYP2D6, and tamoxifen is activated to endoxifen by CYP2D6. Inhibition may raise tamoxifen levels while reducing endoxifen formation, potentially compromising efficacy.
What this interaction means in plain words
Fedratinib and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Tamoxifen belongs to Endocrine.
Why it happens
Fedratinib inhibits CYP2D6 and CYP3A4, altering tamoxifen biotransformation.
What to do
Monitor for tamoxifen adverse effects and loss of response. Consider whether an alternative therapy is appropriate if long-term co-administration is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Tamoxifen?
MediHelp rates the interaction as moderate. Fedratinib and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and CYP2D6, and tamoxifen is activated to endoxifen by CYP2D6. Inhibition may raise tamoxifen levels while reducing endoxifen formation, potentially compromising efficacy.
How serious is the interaction between Fedratinib and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tamoxifen adverse effects and loss of response. Consider whether an alternative therapy is appropriate if long-term co-administration is needed.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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