Drug interactions
Fedratinib + Timolol
Severity: Moderate
Fedratinib and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP2D6, the main enzyme metabolizing timolol. Raised timolol exposure may cause bradycardia, hypotension or bronchospasm, mostly with oral timolol or in poor metabolizers.
What this interaction means in plain words
Fedratinib and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Timolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated timolol metabolism by fedratinib.
What to do
Monitor heart rate and blood pressure and reduce the timolol dose if bradycardia or hypotension appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Timolol?
MediHelp rates the interaction as moderate. Fedratinib and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP2D6, the main enzyme metabolizing timolol. Raised timolol exposure may cause bradycardia, hypotension or bronchospasm, mostly with oral timolol or in poor metabolizers.
How serious is the interaction between Fedratinib and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and reduce the timolol dose if bradycardia or hypotension appears.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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