Drug interactions
Felodipine + Iloperidone
Severity: Minor
Felodipine and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has weak CYP3A4 inhibitory activity and may modestly raise felodipine levels. Additive hypotension and orthostasis are also possible, as both agents lower blood pressure.
What this interaction means in plain words
Felodipine and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Iloperidone belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition plus additive vasodilatory and alpha-blocking effects.
What to do
Monitor blood pressure and orthostatic symptoms, particularly at initiation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Felodipine with Iloperidone?
MediHelp rates the interaction as minor. Felodipine and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone has weak CYP3A4 inhibitory activity and may modestly raise felodipine levels. Additive hypotension and orthostasis are also possible, as both agents lower blood pressure.
How serious is the interaction between Felodipine and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly at initiation.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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