Drug interactions
Felodipine + Loperamide
Severity: Minor
Felodipine and Loperamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine may weakly inhibit P-glycoprotein and slightly increase loperamide exposure. Clinical significance is likely small at standard doses.
What this interaction means in plain words
Felodipine and Loperamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Possible weak P-gp inhibition reduces loperamide efflux.
What to do
No specific action is needed at labeled loperamide doses. Avoid higher-than-labeled loperamide use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loperamide
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Loperamide?
MediHelp rates the interaction as minor. Felodipine and Loperamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felodipine may weakly inhibit P-glycoprotein and slightly increase loperamide exposure. Clinical significance is likely small at standard doses.
How serious is the interaction between Felodipine and Loperamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed at labeled loperamide doses. Avoid higher-than-labeled loperamide use.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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