Drug interactions
Felodipine + Mefloquine
Severity: Minor
Felodipine and Mefloquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine is a CYP3A4 substrate and mefloquine is not a clinically established inhibitor, so a meaningful rise in felodipine levels is unlikely. Any effect would more likely be additive hypotension or bradycardia.
What this interaction means in plain words
Felodipine and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible weak effect on CYP3A4 or P-gp; clinical relevance not established.
What to do
No routine adjustment is required; monitor blood pressure and heart rate when starting mefloquine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Mefloquine?
MediHelp rates the interaction as minor. Felodipine and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felodipine is a CYP3A4 substrate and mefloquine is not a clinically established inhibitor, so a meaningful rise in felodipine levels is unlikely. Any effect would more likely be additive hypotension or bradycardia.
How serious is the interaction between Felodipine and Mefloquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor blood pressure and heart rate when starting mefloquine.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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