Drug interactions
Felodipine + Nisoldipine
Severity: Moderate
Felodipine and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two dihydropyridine calcium channel blockers have no therapeutic rationale together and produce additive vasodilation. Hypotension, edema, flushing and reflex tachycardia are more likely.
What this interaction means in plain words
Felodipine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Nisoldipine belongs to Cardiovascular.
Why it happens
Duplicate pharmacodynamic L-type calcium channel blockade, with possible competition for CYP3A4 metabolism.
What to do
Avoid using both; use a single dihydropyridine at an optimized dose or add an agent of a different class.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Felodipine with Nisoldipine?
MediHelp rates the interaction as moderate. Felodipine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two dihydropyridine calcium channel blockers have no therapeutic rationale together and produce additive vasodilation. Hypotension, edema, flushing and reflex tachycardia are more likely.
How serious is the interaction between Felodipine and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both; use a single dihydropyridine at an optimized dose or add an agent of a different class.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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