Drug interactions
Felodipine + Rivaroxaban
Severity: Moderate
Felodipine and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine is a weak CYP3A4 substrate/inhibitor with possible minor P-gp effects, so rivaroxaban exposure may rise slightly. The effect is usually small but could matter in patients with renal impairment, where bleeding risk may increase.
What this interaction means in plain words
Felodipine and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Rivaroxaban belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4 and possibly P-glycoprotein reduces rivaroxaban clearance.
What to do
No adjustment is usually required with normal renal function. In renal impairment, monitor for bleeding signs and reassess the need for rivaroxaban dose or alternative therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Felodipine with Rivaroxaban?
MediHelp rates the interaction as moderate. Felodipine and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine is a weak CYP3A4 substrate/inhibitor with possible minor P-gp effects, so rivaroxaban exposure may rise slightly. The effect is usually small but could matter in patients with renal impairment, where bleeding risk may increase.
How serious is the interaction between Felodipine and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is usually required with normal renal function. In renal impairment, monitor for bleeding signs and reassess the need for rivaroxaban dose or alternative therapy.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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