Drug interactions
Felodipine + Sirolimus
Severity: Moderate
Felodipine and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine may slightly increase sirolimus exposure through transporter or CYP3A4 effects, though the clinical impact appears modest. Sirolimus has a narrow therapeutic range, so levels warrant attention.
What this interaction means in plain words
Felodipine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Sirolimus belongs to Miscellaneous.
Why it happens
Possible inhibition of P-glycoprotein and CYP3A4 by felodipine reduces sirolimus clearance.
What to do
Check sirolimus trough concentrations after starting or stopping felodipine and adjust the dose accordingly. Monitor for sirolimus adverse effects such as hyperlipidemia and cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Felodipine with Sirolimus?
MediHelp rates the interaction as moderate. Felodipine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine may slightly increase sirolimus exposure through transporter or CYP3A4 effects, though the clinical impact appears modest. Sirolimus has a narrow therapeutic range, so levels warrant attention.
How serious is the interaction between Felodipine and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sirolimus trough concentrations after starting or stopping felodipine and adjust the dose accordingly. Monitor for sirolimus adverse effects such as hyperlipidemia and cytopenias.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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