Drug interactions
Felodipine + Succinylcholine
Severity: Minor
Felodipine and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can modestly potentiate neuromuscular blockade from both depolarizing and nondepolarizing agents. With felodipine the clinical effect on succinylcholine is expected to be small, but block may be somewhat prolonged.
What this interaction means in plain words
Felodipine and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Reduced calcium influx at the presynaptic terminal and muscle may decrease acetylcholine release and enhance neuromuscular blockade.
What to do
Monitor neuromuscular function with a nerve stimulator during anesthesia and titrate additional muscle relaxants to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Succinylcholine
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Succinylcholine?
MediHelp rates the interaction as minor. Felodipine and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers can modestly potentiate neuromuscular blockade from both depolarizing and nondepolarizing agents. With felodipine the clinical effect on succinylcholine is expected to be small, but block may be somewhat prolonged.
How serious is the interaction between Felodipine and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator during anesthesia and titrate additional muscle relaxants to response.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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