Drug interactions
Felodipine + Tacrolimus
Severity: Moderate
Felodipine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine may modestly raise tacrolimus concentrations, and tacrolimus may also affect felodipine handling. Elevated tacrolimus can cause nephrotoxicity, neurotoxicity and hyperglycemia.
What this interaction means in plain words
Felodipine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Competition for CYP3A4 metabolism and possible P-glycoprotein inhibition reduce tacrolimus clearance.
What to do
Measure tacrolimus trough levels and renal function after starting, stopping or changing felodipine, and adjust tacrolimus dose as needed. Monitor blood pressure and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Felodipine with Tacrolimus?
MediHelp rates the interaction as moderate. Felodipine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine may modestly raise tacrolimus concentrations, and tacrolimus may also affect felodipine handling. Elevated tacrolimus can cause nephrotoxicity, neurotoxicity and hyperglycemia.
How serious is the interaction between Felodipine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure tacrolimus trough levels and renal function after starting, stopping or changing felodipine, and adjust tacrolimus dose as needed. Monitor blood pressure and edema.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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