Drug interactions
Felodipine + Tazemetostat
Severity: Moderate
Felodipine and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and may reduce felodipine levels. Felodipine, a weak CYP3A4 inhibitor, could slightly raise tazemetostat exposure.
What this interaction means in plain words
Felodipine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, while felodipine weakly inhibits CYP3A4, so each may alter the other's metabolism.
What to do
Monitor blood pressure and adjust the felodipine dose if control is lost. Watch for tazemetostat adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Felodipine with Tazemetostat?
MediHelp rates the interaction as moderate. Felodipine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A4 inducer and may reduce felodipine levels. Felodipine, a weak CYP3A4 inhibitor, could slightly raise tazemetostat exposure.
How serious is the interaction between Felodipine and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust the felodipine dose if control is lost. Watch for tazemetostat adverse effects.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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