Drug interactions
Felodipine + Voriconazole
Severity: Moderate
Felodipine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can substantially raise felodipine concentrations, leading to excessive vasodilation with hypotension, flushing, headache, and peripheral edema. Tachycardia and worsened ischemia can occur in susceptible patients.
What this interaction means in plain words
Felodipine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits intestinal and hepatic CYP3A4, reducing the first-pass and systemic metabolism of felodipine.
What to do
Monitor blood pressure and heart rate and watch for edema after starting voriconazole. Lower the felodipine dose or switch to an alternative antihypertensive if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Felodipine and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Voriconazole?
MediHelp rates the interaction as moderate. Felodipine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can substantially raise felodipine concentrations, leading to excessive vasodilation with hypotension, flushing, headache, and peripheral edema. Tachycardia and worsened ischemia can occur in susceptible patients.
How serious is the interaction between Felodipine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and watch for edema after starting voriconazole. Lower the felodipine dose or switch to an alternative antihypertensive if needed.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
