Drug interactions
Fenfluramine + Frovatriptan
Severity: Moderate
Fenfluramine and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine increases synaptic serotonin by release and reuptake inhibition, and frovatriptan stimulates serotonin receptors. Use together raises the possibility of serotonin syndrome.
What this interaction means in plain words
Fenfluramine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Frovatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effect from serotonin release and receptor agonism.
What to do
Monitor for tremor, clonus, agitation, sweating and hyperthermia, especially at initiation or dose increase. Withdraw the serotonergic agents and give supportive care if serotonin syndrome occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Frovatriptan?
MediHelp rates the interaction as moderate. Fenfluramine and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine increases synaptic serotonin by release and reuptake inhibition, and frovatriptan stimulates serotonin receptors. Use together raises the possibility of serotonin syndrome.
How serious is the interaction between Fenfluramine and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, clonus, agitation, sweating and hyperthermia, especially at initiation or dose increase. Withdraw the serotonergic agents and give supportive care if serotonin syndrome occurs.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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