Drug interactions
Fenfluramine + Hydralazine
Severity: Minor
Fenfluramine and Hydralazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine has serotonergic activity and can affect blood pressure, and it may cause pulmonary hypertension and valvular disease. Hydralazine's antihypertensive effect is not expected to be strongly altered, so any interaction is not well characterized.
What this interaction means in plain words
Fenfluramine and Hydralazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenfluramine belongs to Central Nervous System; Hydralazine belongs to Cardiovascular.
Why it happens
No well-established mechanism; possible pharmacodynamic effects on blood pressure.
What to do
Monitor blood pressure as part of routine fenfluramine cardiac monitoring. No dose change is needed unless blood pressure control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Hydralazine?
MediHelp rates the interaction as minor. Fenfluramine and Hydralazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenfluramine has serotonergic activity and can affect blood pressure, and it may cause pulmonary hypertension and valvular disease. Hydralazine's antihypertensive effect is not expected to be strongly altered, so any interaction is not well characterized.
How serious is the interaction between Fenfluramine and Hydralazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure as part of routine fenfluramine cardiac monitoring. No dose change is needed unless blood pressure control changes.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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