Drug interactions
Fenfluramine + Insulin glulisine
Severity: Moderate
Fenfluramine and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine may improve peripheral glucose uptake and so enhance the effect of insulin glulisine, increasing the chance of hypoglycemia. Fenfluramine is now used mainly for seizure syndromes.
What this interaction means in plain words
Fenfluramine and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Insulin glulisine belongs to Endocrine.
Why it happens
Additive effect from enhanced peripheral glucose uptake.
What to do
Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Insulin glulisine?
MediHelp rates the interaction as moderate. Fenfluramine and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine may improve peripheral glucose uptake and so enhance the effect of insulin glulisine, increasing the chance of hypoglycemia. Fenfluramine is now used mainly for seizure syndromes.
How serious is the interaction between Fenfluramine and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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