Drug interactions
Fenofibric acid + Fosphenytoin
Severity: Minor
Fenofibric acid and Fosphenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosphenytoin is converted to phenytoin, an enzyme inducer, which could modestly lower fenofibric acid exposure. The clinical effect is probably small because fenofibric acid is not primarily CYP3A4-cleared.
What this interaction means in plain words
Fenofibric acid and Fosphenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibric acid belongs to Cardiovascular; Fosphenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4 and glucuronidation, theoretically increasing fenofibric acid clearance.
What to do
Check the lipid profile after starting or stopping the anticonvulsant and adjust the dose if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Fenofibric acid with Fosphenytoin?
MediHelp rates the interaction as minor. Fenofibric acid and Fosphenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosphenytoin is converted to phenytoin, an enzyme inducer, which could modestly lower fenofibric acid exposure. The clinical effect is probably small because fenofibric acid is not primarily CYP3A4-cleared.
How serious is the interaction between Fenofibric acid and Fosphenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the lipid profile after starting or stopping the anticonvulsant and adjust the dose if the response is inadequate.
What other medicines interact with Fenofibric acid?
MediHelp also lists interactions of Fenofibric acid with, for example, Atorvastatin, Chlorpropamide, Cholestyramine. The full list is on the Fenofibric acid page.
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