Drug interactions
Fenofibric acid + Insulin degludec / insulin aspart
Severity: Minor
Fenofibric acid and Insulin degludec / insulin aspart: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates may modestly improve insulin sensitivity and lower glucose, which can add to the effect of insulin. Hypoglycemia is possible if insulin doses are not reviewed.
What this interaction means in plain words
Fenofibric acid and Insulin degludec / insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive glucose-lowering through improved insulin sensitivity from fibrate PPAR-alpha activity.
What to do
Monitor blood glucose when fenofibric acid is started or stopped and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Frequently asked questions
Can I take Fenofibric acid with Insulin degludec / insulin aspart?
MediHelp rates the interaction as minor. Fenofibric acid and Insulin degludec / insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fibrates may modestly improve insulin sensitivity and lower glucose, which can add to the effect of insulin. Hypoglycemia is possible if insulin doses are not reviewed.
How serious is the interaction between Fenofibric acid and Insulin degludec / insulin aspart?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fenofibric acid is started or stopped and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Fenofibric acid?
MediHelp also lists interactions of Fenofibric acid with, for example, Atorvastatin, Chlorpropamide, Cholestyramine. The full list is on the Fenofibric acid page.
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