Drug interactions
Fenofibric acid + Pitavastatin
Severity: Moderate
Fenofibric acid and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibric acid taken with a statin may add to the risk of myopathy and rhabdomyolysis. The risk is lower than with gemfibrozil but is greater in older patients, those with renal impairment or diabetes, and at higher statin doses.
What this interaction means in plain words
Fenofibric acid and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibric acid belongs to Cardiovascular; Pitavastatin belongs to Cardiovascular.
Why it happens
Additive muscle toxicity of fibrates and statins; no major pharmacokinetic interaction is established with pitavastatin.
What to do
Use the lowest effective doses and instruct the patient to report muscle pain, weakness or dark urine. Measure CK if symptoms occur and discontinue if myopathy is confirmed or suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Frequently asked questions
Can I take Fenofibric acid with Pitavastatin?
MediHelp rates the interaction as moderate. Fenofibric acid and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenofibric acid taken with a statin may add to the risk of myopathy and rhabdomyolysis. The risk is lower than with gemfibrozil but is greater in older patients, those with renal impairment or diabetes, and at higher statin doses.
How serious is the interaction between Fenofibric acid and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and instruct the patient to report muscle pain, weakness or dark urine. Measure CK if symptoms occur and discontinue if myopathy is confirmed or suspected.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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