Drug interactions
Fenoldopam + Metoclopramide
Severity: Minor
Fenoldopam and Metoclopramide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoldopam is a peripheral dopamine D1 agonist, whereas metoclopramide is a dopamine D2 antagonist. Their effects on dopamine receptors oppose each other, although fenoldopam does not cross the blood-brain barrier appreciably, so central effects are unlikely and any change in renal or vascular response is uncertain.
What this interaction means in plain words
Fenoldopam and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing dopamine receptor activity (D1 agonism versus D2 antagonism), mainly peripheral for fenoldopam.
What to do
Monitor blood pressure and renal response during short-term fenoldopam infusion if metoclopramide is given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Fenoldopam with Metoclopramide?
MediHelp rates the interaction as minor. Fenoldopam and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenoldopam is a peripheral dopamine D1 agonist, whereas metoclopramide is a dopamine D2 antagonist. Their effects on dopamine receptors oppose each other, although fenoldopam does not cross the blood-brain barrier appreciably, so central effects are unlikely and any change in renal or vascular response is uncertain.
How serious is the interaction between Fenoldopam and Metoclopramide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal response during short-term fenoldopam infusion if metoclopramide is given.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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