Drug interactions
Fentanyl + Metoclopramide
Severity: Moderate
Fentanyl and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastric emptying and oppose the prokinetic action of metoclopramide, and both drugs cause CNS depression. Together they may increase sedation and reduce metoclopramide's gastrointestinal benefit.
What this interaction means in plain words
Fentanyl and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Pharmacodynamic antagonism at the gut (opioid-reduced motility versus prokinetic effect) plus additive CNS depression.
What to do
Monitor sedation and respiratory status, and reassess whether metoclopramide is achieving its intended effect. Adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Metoclopramide?
MediHelp rates the interaction as moderate. Fentanyl and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastric emptying and oppose the prokinetic action of metoclopramide, and both drugs cause CNS depression. Together they may increase sedation and reduce metoclopramide's gastrointestinal benefit.
How serious is the interaction between Fentanyl and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and reassess whether metoclopramide is achieving its intended effect. Adjust doses as needed.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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