Drug interactions
Fentanyl + Tasimelteon
Severity: Minor
Fentanyl and Tasimelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tasimelteon can cause somnolence, and with fentanyl may add to sedation. The clinical effect is probably modest, as tasimelteon has limited respiratory depressant activity.
What this interaction means in plain words
Fentanyl and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Tasimelteon belongs to Central Nervous System.
Why it happens
Mild additive CNS depression from melatonin receptor agonism with opioid effects.
What to do
Counsel patients about additive drowsiness and caution with driving. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Tasimelteon
Frequently asked questions
Can I take Fentanyl with Tasimelteon?
MediHelp rates the interaction as minor. Fentanyl and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tasimelteon can cause somnolence, and with fentanyl may add to sedation. The clinical effect is probably modest, as tasimelteon has limited respiratory depressant activity.
How serious is the interaction between Fentanyl and Tasimelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and caution with driving. No dose change is usually needed.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
