Drug interactions
Fentanyl + Teclistamab
Severity: Moderate
Fentanyl and Teclistamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teclistamab causes cytokine release, which can transiently suppress CYP enzymes and raise fentanyl exposure. This may increase opioid effects such as sedation and respiratory depression.
What this interaction means in plain words
Fentanyl and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Teclistamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 reduces fentanyl metabolism.
What to do
Monitor for opioid toxicity during step-up dosing and during and after CRS. Reduce the fentanyl dose if signs of excess appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
Frequently asked questions
Can I take Fentanyl with Teclistamab?
MediHelp rates the interaction as moderate. Fentanyl and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teclistamab causes cytokine release, which can transiently suppress CYP enzymes and raise fentanyl exposure. This may increase opioid effects such as sedation and respiratory depression.
How serious is the interaction between Fentanyl and Teclistamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for opioid toxicity during step-up dosing and during and after CRS. Reduce the fentanyl dose if signs of excess appear.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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