Drug interactions
Fentanyl intranasal + Metoclopramide
Severity: Moderate
Fentanyl intranasal and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl causes sedation and respiratory depression, and metoclopramide adds to drowsiness. Opioids also slow gastric emptying and counteract the prokinetic action of metoclopramide.
What this interaction means in plain words
Fentanyl intranasal and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with opioid antagonism of metoclopramide's prokinetic effect.
What to do
Monitor sedation and respiratory rate, and reduce doses if drowsiness develops. Expect reduced prokinetic benefit.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Fentanyl intranasal with Metoclopramide?
MediHelp rates the interaction as moderate. Fentanyl intranasal and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl causes sedation and respiratory depression, and metoclopramide adds to drowsiness. Opioids also slow gastric emptying and counteract the prokinetic action of metoclopramide.
How serious is the interaction between Fentanyl intranasal and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, and reduce doses if drowsiness develops. Expect reduced prokinetic benefit.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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