Drug interactions
Fentanyl intranasal + Propofol
Severity: Major
Fentanyl intranasal and Propofol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl and propofol act synergistically to depress consciousness, breathing and blood pressure. Together they may cause profound sedation, apnea and hypotension.
What this interaction means in plain words
Fentanyl intranasal and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism and propofol's GABAergic action.
What to do
Reduce propofol and fentanyl doses and titrate to effect. Monitor ventilation, oxygen saturation and blood pressure continuously with airway equipment ready.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propofol
Frequently asked questions
Can I take Fentanyl intranasal with Propofol?
MediHelp rates the interaction as major. Fentanyl intranasal and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fentanyl and propofol act synergistically to depress consciousness, breathing and blood pressure. Together they may cause profound sedation, apnea and hypotension.
How serious is the interaction between Fentanyl intranasal and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce propofol and fentanyl doses and titrate to effect. Monitor ventilation, oxygen saturation and blood pressure continuously with airway equipment ready.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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